• Users Online: 135
  • Print this page
  • Email this page
Year : 2020  |  Volume : 10  |  Issue : 3  |  Page : 134-138

Safety and efficacy of streptokinase, tenecteplase, and reteplase in patients diagnosed with ST-elevation myocardial infarction: A comparative study

1 Department of Clinical Pharmacy and Pharm.D., Vaagdevi College of Pharmacy, Warangal, Telangana, India
2 Department of Cardiology, Kakatiya Medical College, Mahatma Gandhi Memorial Hospital, Warangal, Telangana, India

Correspondence Address:
Dr. Sheshagiri Sharvana Bhava Bandaru
Department of Clinical Pharmacy and Pharm.D., Vaagdevi College of Pharmacy, Hanamkonda, Warangal - 506 001, Telangana
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JICC.JICC_62_20

Rights and Permissions

Objective: Our primary objective was to compare the efficacy of streptokinase (SK), tenecteplase, and reteplase by studying patients' electrocardiogram Electrocardiogram(ECG) pre and post thrombolysis. The secondary objectives were to assess chest pain relief using Numerical Pain Rating Scale score and also to compare the side effects (bleeding, hypotension, and anaphylaxis) of three drugs. Materials and Methods: This study is a multicentric, prospective, randomized, comparative study. This study was conducted on 150 patients of ST-elevation myocardial infarction admitted in the wards/ICCU- Intensive Coronary Care Unit, Department of Cardiology, Mahatma Gandhi Memorial Hospital and Rohini Superspeciality Hospital. They were selectively divided into three groups. Group A consisted of patients who received SK (50), Group B who received tenecteplase (50), and Group C who received reteplase (50). The study period was 6 months. The follow-up was done in all the patients during their inhospital stay. Results: Post thrombolysis, reteplase, tenecteplase, and SK led to mean ST-Segment reduction of 64.9 ± 19.77, 52.43 ± 34.57, and 46.97 ± 33.09, respectively. The comparison between the three drugs revealed a significant difference (P = 0.0103). Conclusion: This study concluded that reteplase is most efficacious in the resolution of ST-elevation and also safer than other thrombolytics used.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded258    
    Comments [Add]    

Recommend this journal