• Users Online: 169
  • Print this page
  • Email this page
Year : 2020  |  Volume : 10  |  Issue : 3  |  Page : 121-127

Evaluation of N-terminal pro B-type natriuretic peptide and echocardiographic parameters in congestive heart failure patients with pre- and post-cardiac resynchronization therapy

1 Department of Cardiac Services, Dharamshila Narayan Hridayala Hospital, Delhi, India
2 Department of Cardiology, Rajiv Gandhi Super Specialty Hospital, Delhi, India
3 Department of Anesthesiology, Rajiv Gandhi Super Specialty Hospital, Delhi, India
4 Department of Critical Care, Rajiv Gandhi Super Specialty Hospital, Delhi, India

Correspondence Address:
Dr. Praveen Singh
Rajiv Gandhi Super Specialty Hospital, Delhi
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JICC.JICC_49_20

Rights and Permissions

Introduction: Cardiac resynchronization therapy (CRT) has rapidly evolved as a standard therapy for heart failure (HF) patients. Higher levels of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are typically used in the diagnosis of HF. Materials and Methods: A prospective, observational study of 60 patients with CRT was evaluated with clinical, laboratory and echocardiographic parameters. All patients underwent clinical examination, 6-min walk test, 12-lead electrocardiogram, two-dimensional echocardiographic with Doppler evaluations and NT-proBNP determination. Results: After effective CRT in patients, there was significant improvements in New York Heart Association functional class and 6-min walked distance along with significant decrease in mean QRS width and NT-proBNP plasma levels at 3 and 6 months' follow-up (P < 0.05). The repeat echocardiogram at 3 and 6 months' follow-up showed a significant reduction in the left ventricular end-systolic volume, left ventricular end diastolic volume, and significant left ventricular ejection fraction (LVEF) improvement (P < 0.05). No significant reduction in left ventricle (LV) diameters over 3 and 6 months' follow-up with a significant reduction in the MR severity after 6 months were observed (P < 0.05). At 6 months' follow-up, 75% patients (n = 45) were responders showing concordance between clinical, echocardiographic and NT-proBNP definitions of CRT response while 25% patients (n = 15) were nonresponders. The change in NT-proBNP levels between pre-CRT and 6 months' post CRT was significantly more important in responders than in nonresponders (P < 0.001). Conclusion: The present study shows the clinical benefit of treating patients with CRT and points to the reverse ventricular remodeling, with sustained decrease in LV volumes, plasma NT-proBNP, increase in LVEF, and decrease of the severity of mitral valve regurgitation.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded67    
    Comments [Add]    

Recommend this journal