• Users Online: 45
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 3  |  Page : 136-140

Fragmented QRS complex is independently associated with coronary microvascular function in asymptomatic patients with diabetes mellitus


Department of Cardiology, Zagazig University Hospital, Zagazig, Egypt

Correspondence Address:
Prof. Ragab A Mahfouz
Department of Cardiology, Zagazig University, Zagazig
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JICC.JICC_37_19

Rights and Permissions

Aim: We aimed to investigate the relation between fragmented QRS (fQRS), coronary flow reserve (CFR), and cardiac dysfunction in asymptomatic patients with type 2 diabetes mellitus (DM). Subjects and Methods: Prospectively, 129 participants with DM (83 males; mean age: 49 ± 12 years). Surface electrocardiograms of all participates were analyzed for the presence of fQRS. Furthermore, individuals were evaluated for CFR, using transthoracic echocardiography with adenosine (0.14 μg/kg). They underwent both conventional and tissue Doppler imaging to evaluate cardiac functions. Lipid profile and fasting blood glucose were obtained. Results: CFR <2.0 was found in 74 (57%), while fQRS was detected in 80 (62%). Individuals with reduced CFR had a higher prevalence of fQRS compared with those with preserve CFR (96% vs. 16%, P < 0.001). Patients with fQRS had a lower CFR compared with those without fQRS (1.6 ± 0.3 vs. 2.7 ± 0.5, P < 0.001). The number of fQRS was inversely correlated with CFR (P < 0.001), S' wave (P < 0.01), and positively correlated with E/e' (P < 0.01), left atrial volume index (P < 0.02), triglycerides/high-density lipoprotein-cholesterol ratio (P < 0.01), and fasting blood sugar (P < 0.05). In addition, reduced CFR was closely correlated with increased E/e' ratio (P < 0.01) and lower S-wave (P < 0.03). On multivariate analysis, fQRS and CFR were independently associated (P < 0.001). ROC revealed that the number of QRS ≥3 was the optimal number (area under the curve = 0.92) to predict microvascular dysfunction. Conclusions: fQRS in asymptomatic patents with DM is associated with subclinical microvascular and left ventricular diastolic dysfunction. These findings revealed that the fQRS in the surface electrocardiography could be considered a simple marker for microvascular dysfunction in patients with DM.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed69    
    Printed2    
    Emailed0    
    PDF Downloaded10    
    Comments [Add]    

Recommend this journal