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REVIEW ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 1  |  Page : 1-6

Pulmonary hypertension in people living with HIV/AIDS


Department of Cardiology, Fortis Escorts Heart Institute, New Delhi, India

Correspondence Address:
Dr. Shailesh Singh
Fortis Escorts Heart Institute, Okhla Road, New Delhi - 110 025
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JICC.JICC_6_19

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Pulmonary hypertension (PH) can be defined as a group of disorders characterized by an elevated mean pulmonary arterial pressure (≥25 mmHg) at rest. The exact pathophysiologic mechanism underlying the development of PH in HIV/AIDS patient is unknown. Various hypotheses have been proposed to explain the genesis of PAH in HIV/AIDS patients. These theories have talked about the role of HIV itself, opportunistic infections, inflammation, and endothelial cell dysfunction. The role of highly active antiretroviral therapy (HAART) on the outcome of PH secondary to HIV is still controversial. Various guidelines and bodies have suggested that HIV–PAH, because of the similar disease process as idiopathic PAH, may require the same treatment as PAH in the general population.


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